Browser hijacking is probably the most dangerous form of "malware" because it allows an attacker to steal your online identity.
In June of 2009, cyber criminals stole $415,000 from Bullitt County Kentucky by infecting the county treasurer's PC, creating fake employees, and wiring funds to bank accounts abroad. Microsoft's Internet Explorer is the software most susceptible to this type of attack.
The most foolproof way to prevent hijackers from infecting your PC is to use a "read only" operating system, or "Live CD" that does not open your hard drive, such as Ubuntu or Knoppix, for your online banking transactions.